49
22
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8313 |
HCH6-1
|
Others | Others |
HCH6-1 是甲酰肽受体 1 的竞争性二肽拮抗剂。它能够抑制 fMLF (FPR1激动剂) 特异性激活的人中性粒细胞的趋化性、超氧阴离子生成和弹性酶释放。动物实验中,它对急性肺损伤具有保护作用,可用于研究 FPR1 参与的炎症性肺部疾病。 | |||
T40423 |
L48H37
|
||
L48H37 is a chemically stable analog of Curcumin. It exhibits potent inhibitory properties against myeloid differentiation protein 2 (MD2), acting as a specific inhibitor. Its mechanism involves inhibiting the interaction and signaling transduction of LPS-TLR4/MD2. L48H37 is primarily utilized in sepsis and lung injury research [1]. | |||
T6986 |
Sivelestat
ONO5046,EI546,西维来司他,LY544349 |
Others; SARS-CoV; Serine Protease | Microbiology/Virology; Others; Proteases/Proteasome |
Sivelestat (ONO5046) 是一种选择性的中性粒细胞弹性蛋白酶抑制剂,其 IC50值为 44 nM,Ki 值为 200 nM。它有潜力研究 COVID-19 的急性肺损伤、急性呼吸窘迫综合征或弥散性血管内凝血。 | |||
T2663 |
GTS-21 dihydrochloride
GTS 21 dihydrochloride,DMXB-A,DMBX-anabaseine |
5-HT Receptor; AChR | GPCR/G Protein; Neuroscience |
GTS-21 dihydrochloride (DMBX-anabaseine) 是一种选择性 α7 烟碱乙酰胆碱受体激动剂,具有抗炎和增强认知的活性。它也是一种拮抗剂,对人α4β2的 Ki 为20 nM,对5-HT3A 受体的 IC50为3.1 μM。 | |||
TP1016L |
Aviptadil Acetate
醋酸阿肽地尔,阿肽地尔,Vasoactive Intestinal Peptide acetate salt |
RAAS; SARS-CoV | Endocrinology/Hormones; Microbiology/Virology |
Aviptadil Acetate (Vasoactive Intestinal Peptide acetate salt) 是模拟血管活性肠多肽类似物,具有血管舒张效应。它可诱导肺血管舒张并抑制血管 SMC 的增殖和血小板聚集。它可用于研究 SARS-CoV-2 引起的肺纤维化、肺动脉高压和呼吸衰竭。 | |||
T40612 |
Manganese(salen) chloride
EUK-8 |
Others | Others |
Manganese(salen) chloride (EUK-8) 是超氧化物歧化酶和过氧化氢酶的一种模拟物,具有氧自由基清除性能。它可减轻内毒素血症猪的急性肺损伤。 | |||
T77582 |
Anti-inflammatory agent 51
|
NF-κB | NF-κB |
Anti-inflammatory agent 51 是一种具有抗炎活性和潜在抗肿瘤活性的酰胺/磺酰胺衍生物,对 NF-κB 激活有抑制作用,可用于研究急性肺损伤和溃疡性结肠炎。 | |||
T39719 |
Nrf2 activator-1
Nrf2 activator-1 |
Nrf2 | Immunology/Inflammation |
Nrf2 activator-1 是一种有效的 NF-E2 相关因子 2 (Nrf2) 激活剂。Nrf2 activator-1 可用于研究包括哮喘、急性肺损伤 (ALI)、急性呼吸窘迫综合征 (ARDS) 和肺纤维化等 COPD 和其他呼吸系统疾病。 | |||
T21493 |
Cyclosporin H
|
Others | Others |
Cyclosporin H 是一种 FPR-1(甲酰肽受体 1) 的选择性强效抑制剂。它缺乏 Cyclosporin A 具有的免疫抑制活性。它是一种病毒转导增强剂,可使人脐带血来源的造血干细胞和祖细胞中慢病毒转导增强 10 倍。它与雷帕霉素或前列腺素 E2 联合使用时表现出累加效应。 | |||
T20762 |
Sivelestat sodium tetrahydrate
ONO-5046 sodium tetrahydrate,Elaspol,ONO 5046,ONO5046 sodium tetrahydrate,Elaspol sodium tetrahydrate,ONO-5046,Sivelestat Sodium,Sivelestat Sodium Hydrate,ONO5046 |
Serine Protease | Proteases/Proteasome |
Sivelestat sodium tetrahydrate (ONO5046 sodium tetrahydrate) 是竞争性的人类中性粒细胞弹性蛋白酶的抑制剂,其 IC50 值为 44 nM, Ki 值为 200 nM。Sivelestat (EI546) sodium tetrahydrate 有潜力用于 COVID-19的急性肺损伤/急性呼吸窘迫综合征或弥散性血管内凝血的研究。 | |||
T0189L |
Pemetrexed disodium
培美曲塞二钠盐,LY-231514,LY231514 disodium,培美曲塞二钠,Pemetrexed |
Apoptosis; DHFR; DNA/RNA Synthesis; Antifolate; Autophagy | Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism |
Pemetrexed disodium (LY-231514) 是一种叶酸拮抗剂,用于治疗非小细胞肺癌和恶性间皮瘤。它抑制胸苷酸合成酶,二氢叶酸还原酶和甘氨酰胺核苷酸甲酰转移酶的Ki 分别为 1.3 nM,7.2 nM 和 65 nM。 | |||
T11518L |
GW274150
|
NOS | Immunology/Inflammation |
GW274150 是一种具有口服活性,选择性和高效性的 NADPH 依赖型人一氧化氮合成酶 (iNOS) (Kd=40 nM) 和大鼠诱导型一氧化氮合酶 (iNOS) 双重抑制剂。GW274150 对人和大鼠的内皮一氧化氮合酶 (eNOS) 和神经元一氧化氮合酶 (nNOS) 活性较低。在急性肺损伤炎症模型中,GW274150 表现出保护作用。 | |||
T70874 |
Vipoglanstat
|
||
Vipoglanstat is a prostaglandin E synthase inhibitor and an anti-inflammatory. Vipoglanstat ameliorates leukocyte infiltration and lung injury resulting from both endotoxin-induced and sepsis-induced lung injury. | |||
T15354 |
FTY720 (S)-Phosphate
(S)-FTY720 phosphate,(S)-FTY720P |
Others | Others |
FTY720 (S)-Phosphate is an S1P receptor 1 (S1PR1) agonist. It is used in the research of acute inflammatory diseases such as acute lung injury. | |||
T63709 | Nezulcitinib | ||
Nezulcitinib (TD-0903) 是一种吸入的、肺选择性的 pan-Janus kinase (JAK) 抑制剂,能够用于研究 COVID-19 相关急性肺损伤及氧合受损。 | |||
TP1373 |
Ac2-26
|
||
Ac2-26 TFA is an active n-terminal peptide in annexin A1 (AnxA1), which can alleviate acute lung injury caused by ischemia-reperfusion. | |||
TP1321 |
Ac2-26 TFA (151988-33-9 free base)
Ac2-26 TFA |
||
Ac2-26 TFA, an active N-terminal peptide of annexin A1 (AnxA1), attenuates ischemia-reperfusion-induced acute lung injury. Ac2-26 also decreases AnxA1 protein expression, inhibits the activation of NF-κB and MAPK pathways in the injured lung tissue. | |||
T78091 |
(S)-FTY720-phosphonate
|
LPL Receptor | GPCR/G Protein |
FTY720 (S)-Phosphate,作为S1P受体1 (S1PR1) 激动剂,可用于研究急性肺损伤等急性炎症。 | |||
T28247 |
ONO-1714 HCl
ONO-1714,ONO1714,ONO-1714 hydrochloride,ONO 1714 |
||
ONO-1714 is a inducible nitric oxide synthase (NOS-2) inhibitor. ONO-1714 reduces hyperoxic lung injury in mice. ONO-1714 attenuates inflammation-related large bowel carcinogenesis in male Apc(Min/+) mice. ONO-1714 also inhibits neuronal NOS and exerts an | |||
T70145 |
LYRM03
|
||
LYRM03 is an aminopeptidase inhibitor. LYRM03 is also an ubenimex derivative. LYRM03 attenuates LPS-induced acute lung injury in mice by suppressing the TLR4 signaling pathway. LYRM03 effectively attenuates LPS-induced ALI by inhibiting the expression of pro-inflammatory mediators and Myd88-dependent TLR4 signaling pathways in alveolar macrophages. LYRM03 may serve as a potential treatment for sepsis-mediated lung injuries. | |||
T75800 |
Ac2-26 TFA
|
||
Ac2-26 TFA,是膜联蛋白 A1 (AnxA1) 的活性 N-末端肽,可减轻缺血再灌注诱导的急性肺损伤。Ac2-26 还降低 AnxA1 蛋白表达,抑制受损肺组织中NF-κB 和 MAPK 通路活化。 | |||
T35921 |
N-Oleoyl Valine
|
||
N-Oleoyl valine is an endogenous N-acyl amine that acts as an antagonist at the transient receptor potential vanilloid type 3 (TRPV3) receptor, which is involved in thermoregulation. N-Oleoyl valine is increased in mice following cold exposure for up to at least 16 days. Acute lung injury in mice increases the concentration of N-Oleoyl valine in lung tissue. N-acyl amines also promote mitochondrial uncoupling. | |||
T78882 |
NF-κB-IN-12
|
NF-κB | NF-κB |
NF-κB-IN-12 (compound 3h),作为一种NF-κB抑制剂,在急性肺损伤研究中具有应用潜力,其IC50值为1.02 μM。 | |||
TP1373L |
Ac2-26 acetate
|
NF-κB | NF-κB |
Ac2-26 acetate 是一种膜联蛋白 A1(AnxA1) 的活性 N 末端肽。 Ac2-26 acetate 降低 AnxA1 蛋白表达并抑制受损肺组织中 NF-κB 和 MAPK 通路的激活。 Ac2-26 acetate 可减轻缺血再灌注诱导的急性肺损伤。 | |||
T74832 | TRPV4 antagonist 4 | ||
TRPV4 antagonist 4 是一种有效的 TRPV4拮抗剂,IC50值为 22.65 nM。TRPV4 antagonist 4 抑制 TRPV4 电流。TRPV4 antagonist 4 显示出对急性肺损伤的保护作用。 | |||
T61302 |
Anti-inflammatory agent 17
|
||
Anti-inflammatory agent 17 an orally active anti-inflammatory agent, demonstrates potent efficacy in inhibiting the release of IL-6 and TNF-α without causing cytotoxicity in in vitro experiments. Furthermore, in vivo studies confirm its anti-inflammatory activity. Given its attributes, Compound 17 holds promise for investigating Acute lung injury (ALI) [1]. | |||
T38227 |
Quin C1
|
||
Potent and selective FPR2 agonist (EC50 = 15 nM). Induces Ca2+ mobilization in FPR2 but not FPR1-transfected mast cells. Induces neutrophil chemotaxis and degranulation in vitro. Reduces neutrophil and lymphocyte counts in bronchoalveolar lavage fluid in a mouse lung injury model. Anti-inflammatory. Zhou et al (2007) Pharmacological characterization of a novel nonpeptide antagonist for formyl peptide receptor-like 1. Mol.Pharmacol. 72 976 PMID:17652444 |Corminboeuf et al (2014) FPR2/ALXR agonist... | |||
T82464 |
eNOS pT495 decoy peptide
|
||
eNOSpT495 decoy peptide是一种特异性肽,旨在阻止T495磷酸化从而减少eNOS解偶联和线粒体再分布,该肽常用于研究呼吸机诱导的肺损伤。 | |||
T63261 | iNOs-IN-3 | ||
iNOs-IN-3 是口服具有活力的一氧化氮合成酶 (iNOS) 抑制剂,IC50 值为 3.342 μM,表现出抗炎作用,能够用于研究 LPS 诱导的急性肺损伤 (ALI) 。 | |||
T80954 |
TREM-1 inhibitory peptide M3
|
||
TREM-1 inhibitory peptide M3为一种配体依赖的TREM-1拮抗剂。该化合物能够有效抑制全身及肺部促炎细胞因子与趋化因子的产生,有助于缓解急性肺损伤。 | |||
T36623 |
Antileukinate
|
||
Antileukinate is a synthetic hexapeptide with an acetylated amino terminus and an amidated carboxyl terminus that inhibits the binding of CXC chemokines to the chemokine receptor CXCR2. It inhibits IL-8 binding to neutrophils (Ki = 2.7-13 μM), prevents neutrophil chemotaxis and β-glucuronidase release, and blocks IL-8-induced skin edema in rabbits. At 53 mg/kg, antileukinate has been shown to protect mice against acute pancreatitis and associated lung injury. | |||
T76767 | Daxdilimab | ||
Daxdilimab 是一种 anti-ILT7单克隆抗体,ILT7 是 pDC 型树突状细胞特有的细胞表面分子。Daxdilimab 可用于 COVID-19 感染的急性肺损伤 (ALI) 的研究。 | |||
T79585 |
Anti-inflammatory agent 50
|
NF-κB | NF-κB |
Anti-inflammatory agent 50 (compound a1)是Fusidic acid的衍生物,有效抑制NO、IL-6及TNF-α等炎症因子,调控炎症介质及抑制MAPK、NF-κB和NLRP3炎症小体信号通路,从而减轻急性肺损伤。 | |||
T38047 |
Maresin 1
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Maresin 1 是由巨噬细胞 (MΦ) 生物合成的小分子化合物,具有显著的抗炎活性,可通过抑制中性粒细胞粘附和降低促炎细胞因子水平来减轻LPS诱导的小鼠肺损伤,可以刺激胞内 Ca2+ 产生和分泌。 | |||
T63761 | ACT-660602 | ||
ACT-660602 是口服具有活力的趋化因子受体 CXCR3 拮抗剂 (IC50: 204 nM)。ACT-660602 能够抑制 T 细胞迁移,并在体内急性肺损伤模型中显示出显著作用。ACT-660602 能够用于研究自身免疫性疾病。 | |||
T68788 | Ellipticine quinone | ||
Ellipticine quinone, also known as NSC-383230, is a Drp1 inhibitor. rpitor1 and Drpitor1a inhibited the GTPase activity of Drp1 without inhibiting the GTPase of dynamin 1. Ellipticine quinone showed greater potency than the current std. Drp1 GTPase inhibitor, mdivi-1, (IC50 for mitochondrial fragmentation are (0.06, and 10 μM, resp.). Ellipticine quinone suppressed lung cancer tumor growth in a mouse xenograft model. Ellipticine quinone also inhibited mitochondrial ROS prodn., prevented mi... | |||
T73382 |
SZM-1209
|
RIP kinase | Apoptosis; NF-κB |
SZM-1209是一种口服活性且特异性RIPK1抑制剂,具有85 nM的Kd值。该化合物展现出对抗坏死性凋亡(necroptosis)高效活性(EC50=22.4 ± 8.1 nM),并能抵抗SIRS(全身炎症反应综合征)及ALI(急性肺损伤)。 | |||
T74799 | NF-κB-IN-8 | NF-κB | NF-κB |
NF-κB-IN-8 是一种化合物,其作用机制为竞争性抑制 LPS 与 MD-2 之间的相互作用。该化合物通过与 MD-2 结合,有效降低炎症因子的产生,并能够抑制 ALP 的酶活性。因此,NF-κB-IN-8 在急性肺损伤(ALI)等炎症性疾病的研究中具有潜在应用价值。 | |||
T78113 |
Tylvalosin
Acetylisovaleryltylosin |
Antibiotic | Microbiology/Virology |
Tylvalosin (Acetylisovaleryltylosin) 是一种具有抗菌和抗病毒特性的广谱大环内酯抗生素。它能够诱导细胞凋亡(apoptosis)、展现抗炎效果、缓解氧化应激,并通过抑制NF-κB的激活减轻急性肺损伤。此外,Tylvalosin 在研究PRRSV感染方面作为抗病毒试剂亦被应用。 | |||
T78371 |
Ac2-26 ammonium
|
||
Ac2-26 ammonium是一种具抗炎作用的annexin 1 N末端肽。该化合物能够通过伴侣介导的自噬(CMA)机制降低溶酶体中的IKKβ蛋白含量,从而改善肺缺血再灌注损伤,并在哮喘大鼠模型中抑制气道炎症以及高反应性的表现。 | |||
T69230 | AZD-1236 | ||
AZD1236 is a potent and reversible inhibitor of human MMP-9 and MMP-12 (IC50 = 4.5 and 6.1nM, respectively), with >10-fold selectivity to MMP-2 and MMP-13 and >350-fold selectivity to other members of the enzyme family. AZD1236 activity is approximately 20 to 50-fold lower at the rat, mouse, and guinea pig orthologues. In acute models of lung injury, AZD1236 inhibited the haemorrhage and inflammation induced by instillation of human MMP-12 into rat lungs by ~80% at 0.81mg/kg, and also abolished ... | |||
T82272 |
Gol-NTR
|
||
Gol-NTR是一种针对高尔基体的选择性和灵敏度极高的探针,由硝基还原酶(NTR)激活,用于可视化急性肺损伤(ALI)及其修复。该探针的检测限低至54.8 ng/mL,适用于监测和评估脓毒症引发的ALI反应。 | |||
T36714 |
Sucrose octasulfate (potassium salt)
|
||
Sucrose octasulfate (SOS), a component of the gastrointestinal protectant sucralfate, is an alkaline aluminum-sucrose complex that inhibits peptic hydrolysis and raises gastric pH, protecting esophageal epithelium against acid injury. It can bind to exosite II of thrombin (KD = ~1.4 μM) and inhibit its catalytic activity (IC50 = 4.5 μM) and, as such, has been used as a surrogate for heparin. Furthermore, SOS has been shown to inhibit tumor growth in mouse melanoma and lung carcinoma models by pr... | |||
T78829 |
JNK2-IN-1
|
JNK | MAPK |
JNK2-IN-1(Compound J27)是一款具有抗炎活性的JNK2抑制剂,其解离常数为79.2 μM。该化合物能通过阻断NF-κB/MAPK信号通路来降低肿瘤坏死因子α(TNF-α)和白细胞介素6(IL-6)的释放,从而减轻脂多糖(LPS)引起的急性肺损伤(ALI)及脓毒症症状。 | |||
T76990 | Suvratoxumab | ||
Suvratoxumab (MEDI4893) 是一种长效且具有亲和力高的人源化抗 α-毒素单克隆抗体(IgG1κ 型)。Suvratoxumab 能有效中和 α-毒素 (一种关键的金黄色葡萄球菌毒力因子)。Suvratoxumab 可提高免疫功能低下的小鼠肺炎模型的存活率并减少肺损伤。Suvratoxumab 还可增强Vancomycin 或Linezolid 的抗菌活性。 | |||
T79658 |
PI3Kδ-IN-14
|
PI3K | PI3K/Akt/mTOR signaling |
PI3Kδ-IN-14(化合物(S)-29)是一种高选择性PI3Kδ抑制剂,具有出色的靶点亲和力(IC50为0.8 nM,Kd为84.8 nM)。该化合物特异性结合至PI3Kδ激酶的ATP结合位点,并通过抑制PI3K/AKT信号通路发挥抗炎作用。此外,PI3Kδ-IN-14在改善急性肺损伤(ALI)方面显示出潜在效果。 | |||
T82251 |
GW274150 dihydrochloride
|
NO Synthase | Immunology/Inflammation |
GW274150 (dihydrochloride) 是高效、选择性的 NADPH 依赖型人诱导型一氧化氮合成酶 (iNOS) (Kd=40 nM) 抑制剂,具有口服活性,同时对大鼠 (iNOS) 也有效。相较于人和大鼠的内皮一氧化氮合酶 (eNOS) 及神经元一氧化氮合酶 (nNOS),其效力显著较低。GW274150 (dihydrochloride) 在急性肺损伤炎症模型中具有保护作用。 | |||
T83768 |
Zofenoprilat
Zofenopril-SH,SQ 26,333 |
||
Zofenoprilat是一种血管紧张素转换酶(ACE; IC50 = 8 nM for the rabbit lung enzyme)的抑制剂,同时也是前体药zofenopril的活性代谢产物。它能够抑制分离的豚鼠小肠中由血管紧张素I或缓激肽诱导的收缩(EC50s = 3 and 1 nM, respectively)。在人类脐静脉内皮细胞(HUVECs)中,Zofenoprilat (10 nM)降低基础内皮素-1分泌和一氧化氮(NO)生成,并阻止TNF-α诱导的活性氧种(ROS)增加以及谷胱甘肽(GSH)水平降低。Zofenoprilat (10 µM)保护初级人类心脏微血管内皮细胞免受多柔比星诱导的细胞毒性。此外,Zofenoprilat (10 µM)还能增加HUVECs中的硫化氢(H2S)生成,以及细胞的黏着、迁移和增殖。在以400 µM浓度使用时,它可以减少Langendorff分离的大鼠心脏灌流缺血再灌注损伤模型中的舒张末压和乳酸脱氢酶(LDH)释放。 | |||
T36486 |
Benpyrine
|
||
Benpyrine is a highly specific and orally active TNF-α inhibitor with a KD value of 82.1 μM. Benpyrine tightly binds to TNF-α and blocks its interaction with TNFR1, with an IC50 value of 0.109 μM. Benpyrine has the potential for TNF-α mediated inflammatory and autoimmune disease research[1]. Benpyrine (5-20 μM; 14 hours; RAW264.7 cells) pretreatment results in a dose-dependent decrease in the phosphorylation of IκBα in RAW264.7 cells (stimulated with 10 ng/mL TNF-α or 1 μg/mL LPS). Benpyrine abo... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T0610 |
Piceatannol
白皮杉醇,trans-Piceatannol,Astringenin |
Apoptosis; Serine/threonin kinase; PKA; Syk; PKC; Autophagy | Angiogenesis; Apoptosis; Autophagy; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; Metabolism; Tyrosine Kinase/Adaptors |
Piceatannol (Astringenin) 是一种Syk 抑制剂,可降低由 TNF 诱导的 iNOS 表达,可研究急性肺损伤。它是存在于各种水果和蔬菜中天然存在的多酚二苯乙烯,可诱导细胞自噬和凋亡,具有抗癌和抗炎特性。 | |||
T3409 |
Plantamajoside
Y0160,C10485,大车前苷,车前子甙 |
Others | Others |
Plantamajoside (Y0160) 是一种苯丙烷类糖苷,从车前Plantago asiaticaL.中分离出来得到。它对 LPS 诱导的急性肺损伤小鼠模型具有保护作用。它对肺部炎症具有潜在的研究价值。 | |||
T2870 |
Matrine
Vegard,苦参碱,Matridin-15-one,Matrinium,α-Matrine,(+)-Matrine |
Mitophagy; Ferroptosis; Opioid Receptor; Autophagy | Apoptosis; Autophagy; Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
Matrine (Vegard) 是一种从槐属植物中分离出来的生物碱,可作为一种κ阿片受体激动剂,有抗肿瘤活性。 | |||
T6S0105 |
Peiminine
贝母素乙,Zhebeinone,Fritillarine,Raddeanine,Verticinone |
Others; Autophagy | Autophagy; Others |
Peiminine (Raddeanine) 是浙贝母中的一种生物碱,具有抗炎症活性。 | |||
T5798 |
Euphorbia Factor L2
千金子素L2,euphorbiafactor L2,大戟因子L2 |
Apoptosis; NF-κB | Apoptosis; NF-κB |
Euphorbia Factor L2 是从大戟种子中分离得到的一种赤藓烷二萜,显示强烈的细胞毒性并通过线粒体途径诱导细胞凋亡,具有抗癌活性。 | |||
T4S1422 |
Praeruptorin E
白花前胡素 E,白花前胡素E |
Others; Calcium Channel | Membrane transporter/Ion channel; Metabolism; Others |
Praeruptorin E 是白花前胡中的一种主要成分,是钙拮抗剂,pD2′值为 5.2。 | |||
T3S0401 |
Piceatannol 3'-O-glucoside
白皮杉醇 3'-O-葡萄糖苷,Piceatannol 3-glycoside,Quzhaqigan,曲札茋苷、白皮杉醇-3'-O-葡萄糖苷 |
Arginase; NO Synthase | Immunology/Inflammation |
Piceatannol 3'-O-glucoside (Piceatannol 3-glycoside) 是大黄的一种活性成分,通过抑制精氨酸酶活性激活内皮细胞一氧化氮合酶,抑制Arginase I 和Arginase II,IC50值分别为 11.22 和 11.06 μM。它可增加肺血氧分压,减少肺间质水肿,从而保护肺损伤。 | |||
T3676 |
Sesamol
1,3-Benzodioxol-5-ol,3,4-Methylenedioxyphenol,芝麻酚 |
Apoptosis; AMPK | Apoptosis; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling |
Sesamol (1,3-Benzodioxol-5-ol) 是芝麻油的主要成分,具有抗氧化和抗肿瘤活性。它是一种自由基清除剂,在 DPPH 实验中,IC50为 5.95±0.56 μg/mL。 | |||
T3902 |
Atractylenolide III
白术内酯 III,ICodonolactone,8β-Hydroxyasterolide |
Apoptosis | Apoptosis |
Atractylenolide III (ICodonolactone) 是白术根茎主要成分,通过诱导细胞色素 c 的释放、上调 Bax 的表达和易位凋亡诱导因子,是治疗人肺癌的潜力。 | |||
TN1936 |
Mogroside III-E
罗汉果皂苷ⅢE |
IL Receptor; TNF; TLR | Apoptosis; Immunology/Inflammation |
Mogroside IIIe 是一种葫芦烷型化合物,从罗汉果中分离得到,可抑制 NO 的释放,具有抗肺纤维化作用。 | |||
T5S0106 |
Peimisine
贝母辛,Ebeiensine |
RAAS; AChR | Endocrinology/Hormones; Neuroscience |
Peimisine (Ebeiensine) 非竞争性拮抗气管平滑肌 M 受体,抑制 Ach 引起的平滑肌收缩。它兴奋 β 受体和拮抗内钙释放,促进一氧化氮释放,可舒张气管平滑肌,有平喘作用。 | |||
T6S1256 |
Ruscogenin
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NOS; NF-κB; NOD-like Receptor (NLR) | Immunology/Inflammation; NF-κB |
Ruscogenin 是一种重要甾体皂苷元,提取自麦冬。它能够抑制 TXNIP/NLRP3炎症体激活和 MAPK 途径,改善脑缺血诱导的血脑屏障功能障碍,具有显著抗血栓、抗炎作用。 | |||
T2854 |
Phillyrin
Forsythin,连翘苷 |
P450; Influenza Virus; AMPK | Chromatin/Epigenetic; Metabolism; Microbiology/Virology; PI3K/Akt/mTOR signaling |
Phillyrin (Forsythin) 是从连翘中分离出来的一种天然产物,具有抗甲型流感病毒的活性,以及抗菌和消炎作用。 | |||
T2S2264 |
Linalool
Linalol,(±)-Linalool,Phantol,沉香醇 |
Apoptosis; IL Receptor; TNF; Endogenous Metabolite; iGluR | Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience |
Linalool (Linalol) 是存在芫荽等植物中的单萜类天然产物,是竞争性NMDA 受体拮抗剂,具有抗肿瘤和抗心脏毒性的作用。它通过激活 Nrf2 诱导抗氧化防御和通过抑制 NF-κB 减少炎症反应来保护其免受 LPS/GalN 诱导的肝损伤,具有镇痛、抗菌和抗炎的特性。 | |||
T6S1572 |
Sauchinone
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ERK; p38 MAPK; NF-κB | MAPK; NF-κB |
Sauchinone 是一种从Saururus chinensis 中获得的非对映异构的木脂素。它通过抑制I-κBα磷酸化和p65核易位来抑制 LPS 诱导的 iNOS,TNF-α 和 COX-2 表达。它具有抗炎和抗氧化活性。 | |||
TN2063 |
Physalin B
NSC-287088 |
Apoptosis; NF-κB; Akt; PI3K; Nrf2; NOD | Apoptosis; Cytoskeletal Signaling; Immunology/Inflammation; NF-κB; PI3K/Akt/mTOR signaling |
Physalin B 是茄科植物的主要活性化合物之一,具有广泛的生物活性,可用于治疗炎症湿疹和疱疹等疾病。Physalin B 通过激活 PI3K/Akt 通路抑制 NF-κB 和 NLRP3,从而改善脂多糖诱导的急性肺损伤造成的炎症反应。Physalin B 通过激活 Nrf2 通路抑制 PDGF-BB 诱导的 VSMC 增殖、迁移和表型转化。Physalin B 通过抑制 LAP2α-HDAC1 介导的胶质瘤相关癌基因 1 的去乙酰化和肝星状细胞活化来发挥抗肿瘤活性。 | |||
T19782 |
Antidesmone
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Antidesmone is one compound mainly isolated from Ajugade cumbers Thunb (Labiatae). Antidesmone prevents acute lung injury via regulating MAPK and NF-κB activities. | |||
T5S0313 |
Liguiritigenin-7-O-D-apiosyl-4'-O-D-glucoside
Liquiritin apioside,甘草苷元-7-O-D-芹糖-4'-O-D-葡萄糖苷 |
Others; TNF | Apoptosis; Others |
Liquiritin apioside has antioxidant property by inducing glutathione (GSH) biosynthesis via the inhibition of cytokines and protected lung epithelial cells against cigarette smoke-mediated oxidative stress, might be as protective agent against epithelial | |||
T79970 |
Taxamairin B
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Taxamairin B是有效的抗炎化合物,能显著抑制LPS诱导的RAW264.7细胞中促炎因子(TNF-α, IL-1β和IL-6)表达及NO、ROS生成,并对LPS引起的急性肺损伤模型小鼠具有保护效果。 | |||
TN4490 | Manassantin B | ERK; BCL; p38 MAPK; TNF; NF-κB; JNK; STAT; Antifection | Apoptosis; JAK/STAT signaling; MAPK; Microbiology/Virology; NF-κB; Stem Cells |
Manassantin B is a potent inhibitor of NF-κB activation by the suppression of transciptional activity of RelA/p65 subunit of NF-κB. It also possesses anti-EBV lytic replication activity. Manassantin B inhibits interleukin-6-induced signal transducer and activator of transcription 3 activation in Hep3B cells, it has potential as a potent anti-inflammatory drug for use in pathological processes such as sepsis or acute lung injury. Manassantin B exerts antifibrotic activity in HSC-T6 cells, in pa... | |||
TN2534 |
1-Hydroxy-2,3,5-trimethoxyxanthone
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IκB/IKK; Calcium Channel; NOS; 5-HT Receptor; COX | GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience; NF-κB |
1-Hydroxy-2,3,5-trimethoxyxanthone (HM-1) has vasodilator action ,which involves both an endothelium-dependent mechanism involving NO and an endothelium-independent mechanism by inhibiting Ca(2+) influx through L-type voltage-operated Ca(2+) channels; a minor contribution to the effects of HM-1 may be related to inhibition of the protein kinase C-mediated release of intracellular Ca(2+) stores. HM-1,at the concentration of 1 ug/mL, can effectively inhibit the osteoclast differentiation in a co-c... | |||
T35624 | Ajoene | ||
Ajoene is a disulfide that has been found inA. sativumand has diverse biological activities, including antibacterial, anticancer, antiplatelet, and antioxidant properties.1,2,3,4It is active against Gram-positive (MICs = 5-160 µg/ml) and Gram-negative bacteria (MICs = 136-200 µg/ml), as well as yeasts (MICs = 10-20 µg/ml).1Ajoene is cytotoxic to mouse melanoma cells (IC50= 18 µM), as well as human colon, lung, mammary, and pancreatic cancer cells (IC50s = 7-41 µM).2It reduces... |